中文名 硫黄素T 英文名 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride 别名 盐基嫩黄 碱性黄1 硫磺素T 硫黄素T 硫黄素 T 碱性黄 1 硫代黄素T 硫代磺素T 硫代黄色素 T 2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物 英文别名 avin T ThiofL C.I. 49005 Thioflavin T Thioflavine T C.I. Basic Yellow 1 LABOTEST-BB LT00451909 Thioflavine T (C.I.No.49005) for synthesis 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride 2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium chloride CAS 2390-54-7 EINECS 219-228-9 化学式 C17H19ClN2S 分子量 318.86 InChI InChI=1/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1 密度 1.301g/cm3 at 20℃ 熔点 211-212 °C (decomp) 蒸汽压 0Pa at 25℃ 溶解度 methanol: soluble1mg/mL 存储条件 Store below +30°C. 外观 Powder 颜色 Yellow to ochre-yellow BRN 3922452 MDL号 MFCD00011944 体外研究 Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission. 安全术语 24/25 - 避免与皮肤和眼睛接触。 危险品运输编号 2811 WGK Germany 3 TSCA Yes Hazard Class 6.1(b) Packing Group III 上游原料 2-(4-氨基苯基)-6-甲基苯并噻唑